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The relatively low concordance values for positivity between the different markers (50 65%) probably reflects not only differences in sensitivity but also that the different markers are identifying different populations of cells: in fact, of the 16 CK19-negative patients, five were PIP positive.
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While the markers are identified solely based on the measured mass, this study illustrates their potential utility.
These phenotypic markers are identified through laborious genetic screens.
An additional 1843 polymorphic SNP markers are identified through next-generation sequencing techniques.
Shorter identical regions of l markers are identified as SHs as well.
Once such candidate markers are identified, unsupervised clustering methods are applied to uncover the disease substructure in the biomarker space.
However, if any markers are identified ineffective, the savings in money, time, and resources may be significant.
Simple sequence repeat markers were identified using the Gramene database (http://www.gramene.org/).org/
Among them, 11 markers were identified in three or more environments.
SNP markers were identified by using HRM analysis (Wittwer et al. 2003).
In addition, 15,106 candidate SSR markers were identified, with 11,037 pairs of PCR primers designed.
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