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In a genome-wide study, markers are factors, while in a metagenome-wide study, markers are continuous variables.
When multiple markers are continuous and normally distributed, Fisher's LDA provides the best linear combination that maximizes the sensitivity over the entire specificity range uniformly under the multivariate normal distribution model [ 11].
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7 8 Other than occult blood, stool tests detecting molecular markers are under continuous development; however, most stool tests are not widely available commercially.
Where we have one marker which is continuous, but where we wish to choose the optimal threshold for that marker, so that the partitioning of the population into obese and non-obese by the marker (self-reported BMI) is in some sense 'closest' to the partitioning by the true measure (clinically measured BMI), the ROC curve can be made use of.
Those are continuous concerns, however.
"They are continuous and organised".
Those are continuous controls.
These are continuous functions.
Diagnostic decisions today are primarily based on molecular markers, and there is continuous research and development of new biomarkers that diagnose diseases more specifically, at an earlier stage, and more rapidly[1].
This continuity has been confirmed in both chick and mouse embryos through the analysis of molecular markers whose expression is continuous from the primitive streak cells into subpopulations of cells in the tailbud region (Gofflot et al., 1997; Knezevic et al., 1998).
A more crucial issue is the way in which continuous markers are analysed.
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Justyna Jupowicz-Kozak
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