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Treating DNA variations as markers and testing such markers in human and experimental populations for co-segregation with disease or other phenotypes of interest, is an approach to elucidating complex traits originally proposed by Botstein et al. (1980), which is in widespread use today.
Having analyzed previously the well-established markers of apoptosis, like Fas/FasL and Hsp27, in combination with gelatinases (MMP-2, MMP-9) in children with CKD [ 13], we decided to widen the area of interest by examining new markers and testing their potential applicability in the pediatric CKD population.
The aim of the study is to bring insight into the presence and function of this color morph by (i) studying the genetic structure of these populations using nine microsatellite markers, and testing for (ii) a potential local diversifying selection and (iii) differences in dispersal capacity between blotched and non-blotched vipers.
QTL mapping of genetic variation affecting, for example, resistance to summer mortality [ 22] or hybrid vigor [ 6] requires a large number of mapped molecular markers and testing for associations between marker genotypes and phenotypes to identify chromosomal regions harbouring genes that directly affect the trait of interest.
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Furthermore, 90 ADHD cases from India were genotyped for these markers and tested for association with ADHD.
Given the strong influence of season on 25(OH D concentrations [19], we evaluated seasonal variation in hemostatic and inflammatory markers, and tested mediation effects of 25(OH D in the observed patterns.
Here we made two novel chimeric selection markers composed of drug resistance genes and fluorescent markers and tested their functions.
Independent introgressions of individual candidate regions were created using linked molecular markers and tested for memory retention.
We developed the SCM2-indel1 marker and tested it in the parental lines.
In this scenario each genome-wide difference in DNA methylation is used as a marker and tested for an association with the trait under study.
We estimated ancestral proportions using a panel of nuclear and mitochondrial ancestry informative markers (AIMs) and tested their association with breast cancer risk.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com