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After adjustment for the above covariates, female sex was associated with higher levels of 29 markers and lower levels of 6 markers.
AA ethnicity was associated with higher levels of 19 markers and lower levels of 6 markers after adjustment for age, BMI, conventional risk factors, prior history of CVD, medication use, and lifestyle factors (Table 5, Figure 2).
After adjustment for age, BMI, conventional risk factors, prior history of CVD, medication use, and lifestyle factors, female sex was associated with higher levels of 29 markers and lower levels of 6 markers (Table 4, Figure 1).
AA ethnicity was associated with higher levels of 19 markers and lower levels of 6 markers, including higher levels of several inflammatory makers, higher leptin and lower adiponectin levels, lower levels of vasodilator-natriuretic peptides, higher levels of vasoconstrictor-antidiuretic peptides and markers of calcification and thrombosis.
Smokers with arthritis had higher inflammatory markers and lower IgG regardless of diagnosis and treatment.
Recently, two cross-sectional studies have found an association between elevated inflammatory markers and lower muscle strength in patients with knee OA [ 6, 7].
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Fructose-fed animals also had significantly higher number of F4/80 positive cells, a macrophages marker, and lower protein concentration of occludin, a tight junction protein [ 31].
Pediatric patients who survived had higher levels of the chemokine regulated on activation, normal T-cell expressed and secreted marker and lower levels of plasminogen activator inhibitor 1, soluble intracellular adhesion molecule, and soluble vascular cell adhesion molecule than did pediatric patients who died.
In the Framingham Off-Spring Study, higher absorption marker concentrations and lower synthesis markers were significant predictors of CVD [36], a finding that is in line with data reported by our research group in patients with known severe aortic stenosis [37].
Hayes et al. [ 6] found that 6-marker haplotypes explained more QTL-variance than 4-marker haplotypes, but had much lower proportions of QTL-variance explained by the markers due to lower marker density and lower LD.
We therefore wanted to test the hypothesis that women with T2DM have lower bone turnover markers (BTM) and lower cortical porosity than those without diabetes, and that higher serum glucose and body mass index (BMI) are associated with lower BTM, and with lower cortical porosity.
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