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This is in line with the aberrant expression of developmental markers and induction of apoptosis observed in Ring1b knockout ES cells.
Yang et al. showed that suppression of TWIST1 expression in highly metastatic mammary carcinoma cells specifically inhibited their ability to metastasise to the lung, while ectopic expression resulted in activation of mesenchymal markers and induction of cell motility [62].
It is possible that colorectal cancers acquire their vasculature both by incorporation of normal vessels of the host (which are recognised by CD34 and other pan-endothelial markers) and induction of new blood vessels, that is, angiogenesis (recognised by CD105).
BM-MSC and SM-MSC were compared for the expression of cell surface markers and induction of MHC class I and class II molecules by interferon (IFN -α2, IFN -α2nd IFN-β.
To this end, plasmid-based approaches (Nakazawa et al., 1999), genomic insertion of resistance markers, and induction of antibiotic resistance using mutagenic agents (Putrament & Baranowska, 1973; Putrament et al., 1978) have been described.
EMT represents a complex physiological process that includes dissolution of adherens junctions, a change to spindle-like cell morphology, cytoskeletal reorganization, increased cell motility, loss of epithelial markers, and induction of mesenchymal markers.
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Intriguingly, EDA within the cellular Fibronectin has been shown to promote metastasis through α9β1integrin mediated activation of pro-oncogenic signaling pathways with consequent repression of epithelial cells markers and the induction of a mesenchymal phenotype, a process referred to as Epithelial-Mesenchymal Transition (EMT 12.
NGF augmentation significantly enhanced cholinergic neuronal markers and facilitated induction of hippocampal LTP.
At the end of treatment, tumours were excised and analysed for proliferation and apoptotic markers and cytokines induction known to be associated to CD44 receptor ligation by specific antibodies (Delaunay et al, 2007).
NGF augmentation significantly enhanced cholinergic neuronal markers and facilitated induction of hippocampal long-term potentiation (LTP); moreover, blockade of endogenous NGF significantly reduced hippocampal LTP and impaired retention of spatial memory [ 79].
Glioma stem cells (GSCs) are remarkably similar to normal neural stem cells in terms of expression of neural stem/progenitor cell markers, and upon induction differentiate into neuronal or glial lineages (Chen et al, 2012).
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