Sentence examples for markers and haplotypes from inspiring English sources
Several research groups have examined osteoarthritis (OA) association with Interleukin-1 (IL-1) region markers and haplotypes.
Recently, Lo et al. reported strong positive association between schizophrenia and GABRB2, demonstrated by single markers and haplotypes of five markers in introns of GABRB2, rs6556547, rs1816071, rs194072, rs252944, and rs187269.
Based on the single markers and haplotypes association results, the q-value for each of these non-independent tests was calculated using the step-up procedure[46].
Haploview was used to determine haplotype structure from control genotypes and to perform association testing for both single markers and haplotypes [57].
FBAT additionally allows for multiallelic test for multiallelic markers and haplotypes, where the overall association and linkage of the marker/ markers is evaluated, circumventing the locus-wise multiple testing issues, but possibly losing some power.
To increase the power to detect informative alleles, the sample set was enriched for DNAs that carried disease-associated single markers and haplotypes as determined in the initial genotyping screen.
We performed genome-wide linkage analysis and refined the linkage area with microsatellite markers and haplotype analysis to define the minimal candidate region.
Genotyping success was > 90% for all three SNP markers, and haplotype estimation achieved > 98% accuracy.
Based on current genetic diversity at microsatellite markers and haplotype distribution, the first refugium was probably located in the central Chefu basin.
Finally, our results prove that LD for short and long distances between markers and haplotype phase for short distances between markers in a crossbred population can be predicted with very high accuracy using genotype information of its parental pure lines.
Genotype-specific amplicons were then tested on segregating individuals in the O3 × R5 population and a diversity panel of apple rootstocks to verify genetic inheritance, linkage to other markers, and haplotype uniqueness.
