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Future prospective trials should assemble a panel of these markers and evaluate the prognostic value of these parameters for differentiating patients with varying clinical outcome.
Thus, our mouse model is a unique and clinically relevant preclinical model for a particular subset of breast cancers, and provides a valuable tool to develop useful molecular markers and evaluate targeted approaches for the treatment of these aggressive malignancies.
Our aim was to study promoter methylation of newly identified epigenetically silenced genes together with already known epigenetic markers and evaluate its separate and concomitant role in glioblastoma genesis and patient outcome.
In order to compare architectonic organization with different markers and evaluate variability of the insula between monkeys, it was necessary to establish an area defined with similar criteria in all cases.
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During the study, patients were monitored before each cycle for medical history, physical evaluation, clinical benefit, serum chemistry and tumour markers, and evaluated for toxicity.
The CSSL19 line was backcrossed to the Nipponbare parent and F3 or F4 lines were genotyped using microsatellite markers and evaluated for nitrogen-induced susceptibility to GUY11.
We also examined seasonal variation in hemostatic and inflammatory markers, and evaluated 25(OH D contribution to the observed patterns using mediation models.
These tumors were analyzed immunohistologically for a set of common mammary tumor markers and evaluated by double blind observations by 2 independent pathologists.
In order to evaluate the reproducibility of the pathway markers across different dataset, we performed cross-dataset experiments, where one dataset was used for selecting the pathway markers, and the other dataset was used for building the classifier based on the selected markers and evaluating its performance.
We compared them in regard to demographic data, treatment and several prognostic markers and evaluated the prognostic value of each particular parameter for overall survival prediction (Table 3).
Recently, some studies have focused on IHC markers and evaluated the expression of thyroid transcription factor-1, Ki-67, P63,P53 and VEGF in PTC lesions [ 40- 42].
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