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Moreover, genomic data open new avenues for studying the molecular epidemiology of E. multilocularis: genotyping studies with larger panels of genetic markers allow the genetic diversity and spatial dynamics of parasites to be evaluated with greater precision.
For example, maternally inherited chloroplast markers allow the assessment of the maternal parent of the hybrids and the direction of hybrid matings.
In addition, neither clinical signs nor clinicopathological markers allow the clinician to predict whether a dog with chronic idiopathic IBD will respond to a change in diet alone, to antibiotics or to corticosteroids [ 4].
Epigenetic markers allow the transmission of gene activity states from one cell to its daughter cells; however, until recently, epigenetic marks were thought to be completely erased and then re-established in each generation.
Cell-type specific gene markers allow the use of precise techniques for cell separation, such as fluorescence-activated cell sorting (FACS) [ 4], or for cell identification, for instance by polymerase chain reaction (PCR).
For crop species lacking a high-quality reference genome, like hexaploid wheat, genetically ordered markers allow the implementation of marker-order−dependent but highly accurate imputation algorithms (e.g., FSFHap) to impute genotypic data with a large proportion of missing data points so that QTL/gene mapping can be done precisely.
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What makes these shorelines unique, however, is their role as distinctive time markers, allowing the order of formation of landforms and sediments to be construed with unprecedented detail.
These markers allowed the group to narrow the suspect region of the chromosome to a 6-million-base-pair stretch of DNA that turned out to contain a promising gene: the -synuclein gene.
Our study has revealed additional potentially useful gene and protein markers allowing the classification of several thyroid pathologies.
Linkage analysis with these markers
Identification of new phenotypic markers allows the continued division of DCs into functionally distinct subsets, as evidenced by the recent separation of CD11c+ mDCs into mDC1 and mDC2 subsets [17] [20].
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