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As mentioned above, the difference in tumor proliferation was assessed by Ki-67 staining, a commonly employed proliferation marker with prognostic value in various human malignancies including breast cancer [52], [53].
In lc SSc patients at presentation, anti-FOXE3p53-62+ can be a marker with prognostic significance.
Furthermore, SERBP1 may represent a novel breast tumour marker with prognostic significance.
Interestingly, ISG15 could function as a novel breast tumour marker with prognostic or predictive significance.
The RNA-binding protein SERBP1 is abundantly expressed in human breast cancer and may represent a novel breast tumour marker with prognostic significance.
FOXM1 may represent a novel breast tumour marker with prognostic significance that could be included into multi-marker panels for breast cancer.
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Several other molecular markers with prognostic and predictive significance in GBMs have been identified [24].
In the case of prostate cancer this is well illustrated by a series of recent studies that have identified stromal characteristics and markers with prognostic and response-predicative significance.
Finding important molecular markers with prognostic significance has become increasingly important.
Regulatory network reconstructions allowed us to identify candidate regulators for an IGVH signature and uncover markers with prognostic implications.
Minichromosome maintenance proteins (MCM) have recently emerged as novel proliferation markers with prognostic implications in several tumour types.
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