However, there has been no established clinical marker, which correlates with the response to the treatment and the prognosis in patients with NSCLC (Clinical practice guidelines for the treatment of unresectable nonsmall cell lung cancer, 1997).
Immunological correlates of protection are measurable and specific biological markers which correlate with protection against disease caused by an infectious pathogen.
As a proof of concept, 51 ovarian cancer tissues were profiled retrospectively for the expression of 30 000 human genes by microarray analysis to identify expression markers which correlate with clinical outcome in response to a combination treatment of taxol and platinum.
In this animal model, hyper-procalcitoninemia was an early systemic marker of sepsis which correlated closely with mortality and had an inverse correlation with serum calcium levels.
In the degranulation assay, the cytotoxicity of NK cells was determined by measuring the cell surface expression of the lysosomal marker, CD107a, which correlates with NK cell cytotoxicity [ 19].
Skn-1a/ Oct11) is a known transactivator of the suprabasal layer marker KRT10 [ 27], which correlated positively with PC1 (Score = 0.89, local-FDR = 6.00 × 10−4), and is also a known repressor for the basal layer marker KRT14 [ 28], which correlated negatively with PC1 (Score = −0.68, local-FDR ~ 0).
Myers et al., the authors of the Seychelles studies, argue in their letter to The Lancet [ 5] that hair mercury concentration is the only methylmercury exposure marker which has been correlated "against actual brain concentrations" [ 10] and that cord blood mercury has not.
5,043 SNP loci were detected among the 2,577 markers on the genetic maps, which correlated with two SNP loci per SLAF marker, and percentages of different SNP types were investigated (Table 3, Additional file 4).
These include hypertrophy, macrophage infiltration (CD11b/TNF α/IL6), apoptosis, β-cell vacuolation, hyperinsulinemia (HI), and stress markers (RL-77/HSP104/TBARS) all of which correlated well with indices for obesity (2-3 fold), IR (1.5-3 fold), and HI (2-3 fold).
Given these data we compared genes which correlated and anti-correlated with TP63 gene expression, as a method for identifying putative novel markers of SCC and AC.
