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The Pi9-Pro marker was unable to differentiate between the Pi2 and Piz-t alleles.
This marker was unable to discriminate between the studied bowel complications despite it being an organ specific protein.
Thus, the marker was unable to serve as a useful adjunctive tool to assess short-term mortality risk in this patient population.
A single measure of this marker was unable to predict incidence or progression of radiographic knee or hip OA, osteophytes, or joint space narrowing in either men or women [ 71].
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As a primary screening tool, this marker is unable to distinguish between normal pathological conditions especially in the so-called "grey zone" (PSA value from 2.5 to 10 ng/mL) [ 24].
The best set of markers associated with response to golimumab treatment included week-4 changes from baseline; however, even these markers were unable to achieve high enough specificity and sensitivity to be routinely useful predictors.
This suppressor cell subset is often identified as CD4+CD25high cells [ 27] or as CD4+FoxP3+ lymphocytes [ 41], even if these markers are unable to uniquely define a regulatory T cell phenotype.
In our study, the classical serum and urine markers were unable to accurately reflect the changes on renal function after both the short- and long-term treatments, despite the presence of renal lesion, which were more pronounced for the longer CsA exposure; that failure demonstrates the need of better biomarkers of renal dysfunction/damage.
The Pi9-Pro marker, however, was unable to differentiate between the Pi2 and Piz-t alleles.
Moreover, the four-marker signature was unable to predict aggressive disease in either H or L TMA (median test AUC of 0.56 (95% CI of 0.44 0.64) and of 0.56 (95% CI of 0.46 0.65), respectively).
Besides the fact that in our hands the CD133 levels in PancTu-1 cells were relatively low, a multiparametric analysis (PCA) using expression values of all pancreatic cancer stem-associated markers [ 7] was unable to differentiate the lines that show a sphere-growing capacity from those that do not.
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CEO of Professional Science Editing for Scientists @ prosciediting.com