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At baseline measurement, at least one serum tumour marker was raised in all patients and all three tumour markers were raised in 13 patients (33%, 95% CIs: 20, 48%).
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At presentation NSE was the most frequently elevated marker, being raised in 81% of patients and significantly higher in extensive as opposed to limited disease, as were LDH and ChrA.
It is used here on molecular data because it is in genetics the question of congruence among markers was raised several years ago.
PCRs were performed as described above except that 1 μl of pooled BAC library DNA was used as template and the annealing temperature for most markers was raised to 60°C to achieve greater specificity.
The potential for unforeseen adverse consequences of setting quality markers was raised by a number of participants and has been recognised as a good reason for piloting before national roll-out [ 37].
There is a growing body of evidence that these endothelial activation markers are raised in patients with SSc and that their levels correlate with disease activity and can be regulated by therapy.
All markers were raised in patients with sustained AKI but only urinary NGAL (uNGAL) and urinary cystatin C were able to distinguish patients with sustained AKI from those with transient or pre-renal AKI.
The finding that NGAL was one of the most highly expressed proteins following ischaemia-reperfusion injury in kidney cells [ 372- 374], and prognostic of kidney damage long before the more traditional marker creatinine was raised significantly, has led to considerable interest in this protein, especially as a marker of renal injury [ 375- 389], and perhaps as a therapeutic [ 375].
Zhao and colleagues reported that the marker CD90 was raised in both MSCs and in prostate cancer stromal fibroblasts, which the authors analysed by quantitative PCR after isolating them from tissues by FACS, using CD90 as a discriminator [ 30].
The $14,000 for the marker and ceremony was raised largely by donations of less than $20 from individuals, including Woody Guthrie devotees and families of farmworkers.
First, the segregation patterns between adjacent GBS markers were compared and a flag was raised when adjacent segregation patterns differed more than 10% (14) of the mapping individuals.
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