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Isolated tumour cells were considered to be 'present' when any single marker was positive.
When considering a combination positive if at least one marker was positive, increased sensitivities but decreased specificities were observed compared to the single tests.
A single molecular marker was positive in 50% of the SLNs, the significance of a positive single molecular marker is yet to be determined.
This marker was positive in at least one of the three samples in six of the 48 tested sudden unexpected death victims.
In accordance with the observations made for the two-marker combinations, the addition of a third or a fourth marker increased sensitivity when considering the combination positive if one marker was positive (with decreased specificity).
We classified patient cases as hormone receptor-positive if either the ER marker or the PR marker was positive, and as hormone receptor-negative if both markers were negative.
Similar(53)
p63, a putative stem cell marker, is positive for basal cells.
Sens = probability marker is positive at screening T years before diagnosis of lethal tumour.
The true positive rate (TPR), or the test sensitivity, is the probability the marker is positive given cancer.
The false positive rate (FPR), or 1 – specificity, is the probability the marker is positive given no cancer.
PPV = probability of lethal tumour given marker is positive at screening NSaved = increase in lives saved per 10,000 individuals screened.
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