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Some trends of marker utility are evident.
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Novel tumour markers with potential clinical utility are thus awaited.
The only breast cancer tumor markers with demonstrated clinical utility are tumor-associated antigens, but their usefulness to follow up patients with metastatic disease can be limited [ 5].
While these sequences are a source of potential presence/absence markers, their utility was not further investigated.
Folate receptor- α was the most specific marker (99.2%); however, its utility is limited by the fact that it was not detectable in the majority of tumours, as previously reported (Shia et al, 2008), resulting in a poor sensitivity (39.3%).
While, messenger RNA (mRNA) signatures from global gene expression profiling have also been put forth as potential prognostic markers for BC [ 5– 8], their utility is limited to specific clinical settings [ 9].
Heat shock protein 70 is a marker of prostate cancer, although its clinical utility is uncertain.
As a stand-alone diagnostic marker with an AUC of only 0.70, its utility is limited.
To validate marker utility, 36 SNP assays were used to evaluate the genetic diversity of 34 diverse oat genotypes.
The utilities are split.
Basic utilities are still wretched.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com