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11 In an open-label, phase I II study, 46 patients with mCRPC treated with a combination of dasatinib and docetaxel experienced a 60% Response Evaluation Criteria In Solid Tumors (RECIST) response rate, 77% disease control rate, as well as stabilization of bone metastases accompanied by decreases in bone marker turnover 12.
While BPs [ 14, 15] and other antiresorptive agents [ 5- 7, 16] have shown promise, mostly structural effects (inhibition of cartilage degeneration [ 12, 14], prevention of osteophytes [ 14] and reduction in bone marker turnover [ 15]) in animal models of OA with pre-emptive treatment, clinical results in knee OA patients have been disappointing, for example, with risedronate [ 17].
Similar(58)
The marker for turnover originated from proteoglycan aggrecan (CS846) and the marker for synthesis of type II procollagen (CPII).
Therefore, in addition to F-FES-PET, we also evaluated whether tumour markers, and bone turnover markers can aid response prediction.
The association between biochemical tumour markers and bone turnover markers and benefit from oestradiol was calculated by a Mann–Whitney U test.
The CMA markers, LAMP-2A and Hsc70, and mitochondrial turnover markers, Drp1, PINK1 and PGC1α also were decreased.
Other bone turnover marker changes were not significant.
Bone turnover marker changes in response to physical activity are well documented.
Cho is considered a marker for cell turnover [4].
Choline is a marker for membrane turnover.
Everolimus added to exemestane significantly decreased bone turnover marker levels at 6 and 12 weeks.
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