We used this map to differentiate homoeologues based on their efficiency in amplifying F. vesca-derived markers and to discover genomic rearrangements among the diploid sub-genomes (homoeologues).
Metabolomic results can be used to classify breast cancer on the basis of tumor biology, to identify new prognostic and predictive markers and to discover new targets for future therapeutic interventions.
Overall, the findings showed a serious need for more comprehensive and larger scale samplings, especially in remote river systems, in combination with molecular analyses using multiple markers, in order to discover more cryptic lineages or undescribed "genetic species" of mahseer.
This study uses the SELDI platform to discover markers of prognosis in a training set of serum samples, and verifies the markers by SELDI in an independent set of serum samples.
Emerging development of MS proteomics provides a fast and sensitive analysis to discover markers or possible HDL roles in diseases.
MLM (Mixed Linear Model) analysis, including population structure and kinship, was used to discover marker-trait associations.
From a clinical point of view, it is imperative to discover markers for early sepsis and AKI diagnosis, as well as for the patients' prognosis, to determine an earlier intervention to save lives.
Since blood is easily and repeatedly accessible clinically and since its collection and processing is readily standardized, we have sought to discover markers of HD in blood that could be useful clinically.
Large-scale expression data have also been used to construct a transcriptional profile of adult skeletal muscle [ 3]; to identify genes preferentially expressed in prostate [ 4], granulocytes [ 5] and thyroid [ 6]; to discover markers of pathological states such as cancer [ 7], and for whole genome structure analysis such as identification of clusters of similarly expressed genes [ 8, 9].
Therefore, we performed ATII cell isolation followed by labeling, multidimensional chromatographic fractionation and isobaric tag for relative and absolute quantitation liquid chromatography tandem mass spectrometry (iTRAQ LC-MS/MS) to discover markers for cellular pathways of activation and injury and followed up on the results using more sensitive immunological methods.
