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We explore, in a two-stage design, how the use of false discovery rate (FDR) can alleviate the burden of a prohibitively strict significance level for single marker tests and still control the number of false positive findings, when there is more than one causal variant.
Second, we applied the false discovery rate to quantify uncertainty across the multiple hypotheses tested in the six single marker tests and the multiple haplotype tests.
For both specific haplotype marker tests and the general comparison of haplotype frequencies by haplotype block, haplotype frequencies and subject-specific expected haplotype indicators were calculated separately for each study using the programme TagSNPs [24].
We screened and identified positive lines by selectable marker tests and PCR analysis with construct-specific primers (Additional file 1: Table S1).
There have been recent dramatic technical improvements in methodology for the early diagnosis of cancer, with remarkable advances being made in tumor marker tests and the diagnostic imaging of cancer.
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It's called the marker test and what it actually measures is not growth hormone but growth hormone's effects — an increase in IGF-1 and an increase in one of the metabolites released when a tendon is being repaired.
The GLM analysis uses a least squares fixed effects linear model and gives two outputs (a) GLM marker test and (b) the allele estimates.
The FSTAT Version 2.9.3 program [38], which applies the Wier and Cockerham algorithm [37], was used to calculate Fst values for each genetic marker tested, and was also used to perform pairwise Fst calculations.
Within a single gene locus, two putative alleles from peach and almond were distinguished through marker test and sequence comparison.
Of note, patients with positive markers were at higher risk for recurrence even 1-2 yeafterfter urine marker testing and negative cystoscopy.
A set of 23 grasspea (L. sativus) accessions and one red pea (L. cicera) accession were used in SSR marker testing and genetic diversity analysis.
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