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Unfortunately, many tumour marker studies have not been reported in a rigorous fashion, and published articles often lack sufficient information to allow adequate assessment of the quality of the study or the generalisability of study results.
Prognostic marker studies have several possible aims, including the desire to understand more about the biology of a disease process.
However, there is increasing awareness that prognostic marker studies have been neglected in the drive to improve medical research.
However, for whatever reason, it is clear that prognostic marker studies have been neglected in the drive to improve medical research.
Many tumor marker studies have shown that BAGE, MAGE-1/3 and GAGE-1/2 are expressed in the majority of different types of ovarian cancer, while not in the normal ovarian tissue or body fluids.
Biochemical bone marker studies have suggested an increase in bone resorption and reduced bone formation in the first week after stroke compared to controls [2], which persisted throughout the first year [3,4].
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Genetic marker studies had pointed to this gene, but could not nail down specific high-risk variants.
By comparing historical and contemporary DNA sequences or markers, studies have been able to assess directly how genetic diversity changes through time in nonmodel organisms.
Although almost all tissue markers studies have been highly promising, almost all of these are based on retrospective series with small sample size and relatively short follow-up.
The MARKER Study has been registered at the Australian and New Zealand Clinical Trials Registry (ACTRN12609000054213).
However, as yet none of the markers studied have proved of sufficient discriminatory power to be employed in a clinical setting.
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