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Differences in marker significance under different analyses may be of interest.
Over 3800 SNP markers are used for QTL interval mapping, thus for each marker significance values are available.
One example given by the authors is the reporting of prognostic marker significance without disclosing extensive manipulation of data for cutoff optimisation and variable selection.
Formal methods of testing marker significance can also be used employing a posterior likelihood ratio test for the model with and without a particular marker included [ 53].
As four comparisons were being made for each marker significance at the 5% level was set at P = 0.0125 (0.05/4).
Similar(55)
WHR and two skin fold measures (TrS and SbS) of cluster 2 also showed nominally significant associations with some of these markers, significance of which were not supported by the permutation test.
For all markers, significance was adjusted for multiple testing using the Bonferroni method, dividing the usual significance level (α = 0.05) by the number of tests performed (αcorrected = 0.05/183 = 0.0002732).
Thus, there is a gap between marker's significance and gene-wise significance.
Additionally, high CD44s expression was a negative prognostic marker with significance in patients with resected NSCLC, particularly those with AC histology, and was independent of tumor stage.
High CD44s expression was a negative prognostic marker with significance in patients with resected NSCLC, particularly those with AC histology, and was independent of tumor stage.
Ki-67 labeling index was predictive for recurrent disease; however, after adjustment for the metastatic expression signature this often used marker lost significance.
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