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Tumour marker sensitivity was clearly related to the site of recurrence, with the lowest sensitivity found in locoregional relapse and the highest in patients with liver metastases.
The effectiveness is determined by the tumor marker sensitivity, and the cost depends on the expense that patients incur for the detection.
Significant values for tests of departures from standard neutral equilibrium of opposite sign seem to support balancing selection on the expressed loci, while cases where demographic signatures are detected at chloroplast markers but not at PIP loci can be conservatively attributed to differences in marker sensitivity.
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To graphically present the results, estimates of sensitivity and specificity of a single marker across studies were summarised in a receiver-operating characteristic (ROC) graph, plotting the markers' sensitivity on the y axis against the 1−specificity on the x axis.
When we combined the results of serum tumor markers, sensitivity and accuracy were not significantly different between NAB combined with serum tumor markers and NAB alone (for all three serum tumor markers, p > 0.05).
This step has to be followed by other phases and markers, sensitivity and specificity need to be tested and established after appropriate validation before efficacy can be assessed using different diagnostic methodologies.
To evaluate the predictive ability of the markers, sensitivity and specificity were estimated within 2, 5 and 8 years because the event of interest is time-dependent (Heagerty et al, 2000).
For tumor markers, sensitivities were also determined as the ratio of the number of subjects in which the marker levels were higher than the previously determined normal range to the number of measured subjects.
Fig. 3 Evaluation of membership functions for fuzzy logic controlled bionanorobot assisted drug delivery system Fig. 4 Diagnosis output for the CA 125 marker versus sensitivity and concentration.
The neuraminidase of all the Indian isolates possessed H275, the marker for sensitivity to the neuraminidase inhibitor Oseltamivir.
All the Indian isolates possessed residue H274 (position 275 in N1 numbering) a known marker for sensitivity to the neuraminidase inhibitor, Oseltamivir [17].
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