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However, marker selection is still a fundamental challenge.
To date molecular markers have improved efficiency of selection largely for traits under simple genetic control and in specific conditions where marker selection is easier/cheaper than phenotypic selection [44] [50].
SNP marker selection is aimed to increase the chances that at least one typed SNP would be in linkage disequilibrium (LD) with the disease causative variant, while at the same time controlling the cost of the study in terms of the number of markers genotyped and sampled.
However, since there are thousands of genes in the nucleus, marker selection is challenging and the majority of nuclear genes occur in small to large gene families.
Cross-species orthology-based marker selection is shown to be a powerful tool to quickly generate a comparative genetic map, which may speed up gene mapping and contribute to the understanding of genome evolution within the Solanaceae family.
The marker selection is probably not the cause of discrepancy since the NCI marker panel for MSI analysis has proven effective in several extracolonic tumor types such as endometrial, ovarian and gastric cancer [ 20, 29].
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The goal of our marker selection was to identify genes whose protein products are consistently found at higher levels in the blood of patients with early stage serous ovarian cancer than in healthy individuals.
A forward marker selection was used as MQM method.
Detailed methods for linkage group construction and marker selection were described in [ 33].
The marker selection was based on both high density genetic map [ 43] and sequence alignment against D5 G. raimondii reference genome sequence.
Although simultaneous evaluation of markers and no need for marker selection are advantageous characteristics of GS, decreasing the number of markers required in the breeding phase might be preferable from the economic viewpoint.
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