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Higher-quality prognostic marker research is desperately needed and is attainable.
These issues have established a 'vicious cycle' in which marker research is under-funded and lacks the rigor of basic laboratory or therapeutic clinical research, and therefore marker use is based on low level data.
An important and consistently observed phenomenon in genomic prognostic marker research is that these predictors provide independent prognostic information when considered together with routine clinical characteristics (for example, tumour size, nodal status, histological grade) in multivariate analysis [ 2, 9].
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Owing to the high prevalence of prostate cancer, tumour marker research still is particularly challenging as PSA is known to have some limitations in its application especially in the diagnostic window of 4 10 ng ml−1 (Partin et al, 1990).
Our preliminary data suggest that deficits in processing fearful and sad affect may be a potential trait marker, although more research is needed to replicate findings and establish if these deficits meet criteria for an endophenotype.
Although some confounding effects can be mitigated by careful study design or by explicitly accounting for these factors when performing marker identification, further research is needed to devise more effective methodologies for this purpose.
Using type X collagen as a marker, this research was designed to examine the alteration of condylar growth in response to mandibular condylar forward positioning.
Given that these increases were similar to findings from various countries and jurisdictions employing different definitions and distinct markers of severity, further research is required to identify and address the cause or causes of the increase in atonic postpartum hemorrhage.
More broadly, these data suggest that aberrant frontostriatal response to rewards may potentially represent a trait marker for MDD, though future research is needed to evaluate the prospective utility of this functional neural endophenotype as a marker of MDD risk.
A major goal of translational cancer research is to identify diagnostic markers, prognostic markers, and markers to predict response to treatment.
While the use of molecular markers in plant breeding and research is well documented [ 18, 19], the application of multiplex PCR in plants is not widely reported due to the difficulties associated with assay development.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com