Molecular markers play important roles in many activities involved in plant breeding, such as studies of genetic diversity [ 20], marker-assisted selections [ 21], and the identification of genes responsible for desirable traits [ 22].
The vWF marker plays an important role in platelet adhesion along the wound sites within the arteries (Sadler 1998; Wu et al. 2008).
Therefore, ALDH1 not only serves as a functional marker of CSCs, but also plays important role in resistance to chemotherapy.
In addition, cartilage oligomeric matrix protein (COMP) is a classical gene marker of chondrogenic differentiation and plays important roles in cell proliferation, adhesion, and differentiation [ 48– 50].
The knowledge of genetic structure based on molecular markers such as microsatellites (5) plays important role in population genetic studies, gene regulation and genome evolution (6 8).
The proteoglycan not only serves as one of the most reliable pericyte markers [ 7, 8], but also plays important roles in pericyte recruitment and interaction with endothelial cells during microvessel development [ 9– 13].
Cox2 plays important roles in breast cancer metastasis to bone [ 26] and increased Cox-2 level was identified as one of the markers for metastasis [ 27].
These findings collectively suggest that hyperhomocysteinemia initiates atherosclerosis by modulating the cholesterol biosynthesis and by significantly inducing the level of other cardiovascular risk factors and markers, which play important role in initiating atherosclerosis.
GATA-4 is a member of the GATA family of zinc finger transcription factors and is an early cardiomyocyte marker, playing an important role in transducing nuclear events that modulate cell lineage differentiation during development [25] [26] and hypertrophy of adult cardiomyocytes [27].
Highly sensitive determination of tumor markers plays an important role in early diagnosis of cancer.
