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Typically, marker platforms have addressed only one of these objectives.
To date, high-density marker platforms have been developed for very few polyploid crops: auto-tetraploid potato [ 31], allo-tetraploid sour cherry [ 5], rose [ 32], and oilseed rape [ 33, 34], as well as the more complex allo-hexaploid wheat [ 35].
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A number of array-based high-throughput marker genotyping platforms have been used in plant breeding, especially marker-assisted selection, to understand crop domestication and plant evolution [ 11].
The same platforms have given rise to marker assisted selection on a genome-wide scale, called genomic prediction or selection [ 16].
In general, animal studies have focused on excess homozygosity on a marker-by-marker basis (Fh) whereas human studies, which have the opportunity to use denser SNP platforms, have focused increasingly but not exclusively on runs of homozygosity (Froh).
By selecting a marker for a specific tumor type, such as PSMA for prostate cancer, affinity-based microfluidic platforms have shown excellent promise.
Platforms have different attributes.
The platforms have sheds and ticket machines.
SNP arrays tend to be robust marker platforms but can have limitations, including the inability to target loci that were not included during the array development (i.e. ascertainment bias) and a relatively high per-sample cost.
Second, the plethora of genetic markers obtained from different genotyping platforms has resurrected the "empty matrix" problem, whereby populations from different studies can barely be compared due to the low overlap of these platforms.
The OmniExpress platform was more successful at imputing Affymetrix 6.0 markers than vice versa; however, both platforms had similar efficacy for imputation of Immunochip SNPs.
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