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In addition, we have used carbon monoxide as a vapour phase marker of whole smoke and finally, produced repeatable biological dose-responses using two independent in vitro systems.
Urinary 8-iso-prostaglandin F2α (8-iso-PGF2α), as marker of whole body oxidative stress, was measured by a previously described and validated enzyme immunoassay method [ 32].
The rationale for this technique is that tyrosine is neither synthesized nor degraded by skeletal muscle and is suited as a marker of whole protein degradation [ 26].
Calprotectin is a neutrophil-derived protein that can be quantified in the feces and has become established as a marker of whole gut inflammation.
In obese subjects, the homeostatic model assessment (HOMA2-S, a surrogate marker of whole body insulin sensitivity) was the most relevant predictive factor of the phosphocreatine-to-ATP ratio (18).
However, Matsuda index, as a marker of whole body insulin sensitivity calculated using plasma glucose and serum insulin levels from 75 g OGTTs, increased from the baseline at both the 1-year and 3-year marks.
Similar(53)
Ho et al. (2003) measured urinary isoprostan 8-epiprostaglandin F2α, a marker of whole-body lipid peroxidation, and serum tumor necrosis factor (TNF -α afTNF -αministering injections of 100 mg/kg CH in corn oil to rafter
In contrast, lathosterol, which is a significant marker of whole-body cholesterol synthesis, was not only elevated in the low-HDL-C cases but also correlated with the plasma LDL-C concentration (j).
Objective: To identify whether saliva flow rate, total protein concentration and osmolality are sensitive non-invasive markers of whole body hydration status, we compared changes in these parameters with changes in body mass during progressive acute dehydration.
It demonstrates that among hepatic markers only ALT is significantly associated with development of type 2 diabetes independent of classic risk factors as well as markers of whole body insulin resistance (HOMA-IR) and sub-clinical inflammation (CRP).
Secondary measures of cellular oxidation that will be measured include 8-hydroxy-deoxy-guanosine (8-OH-dG) reflecting defects in DNA repair capacity, and markers of whole body lipid peroxidation, 8-isoprostane-F2-alpha (8-iso-PGF2α), which have been shown to play a role in breast carcinogenesis [ 49, 82, 83].
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