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As a marker of vessel maturation we considered the presence of a smooth muscle layer around the vascular endothelium.
Pericyte coverage of vasculature is a marker of vessel maturation, hence desmin expression may have use as a marker for microvessel maturation.
To validate the use of the FVIIIRA level in brain homogenates as a marker of vessel density, we compared FVIIIRA level with immunohistochemical measurement of vessel density in the corresponding region of white matter in the contralateral hemisphere.
That this does indeed occur is supported by our finding of a positive correlation between VEGF and FVIIIRA (a marker of vessel density) in two independent autopsy cohorts (Bristol and Oxford).
The notion of dysfunctional tumour vessels is also supported by the observed tendency of positive correlation between microvascular proliferation and capillary transit time (Tc) (Table 2), which is considered a marker of vessel heterogeneity.
To determine the functionality of the E2-induced reconstructed islet vasculature network, we applied in vivo staining for lectin a commonly used marker of vessel functionality [ 33] to a group of mice treated with vehicle or E2.
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Thus, D-dimers could really become a marker of vessels walls instability and modification of their inner morphological structure since first days of life.
We combine physiological and biochemical techniques in an attempt to better detect markers of vessel disease development.
In future studies, the identification of prostate cancer patients most likely to respond to anti-angiogenic therapies, either by measuring levels of immature vessels in pretreatment biopsies, or by global markers of vessel turnover such as with circulating endothelial cells or their progenitors, may be important (Georgiou et al, 2008).
In conclusion, here we utilised the amplitude of enhancement on arterial phase CECT imaging as a surrogate marker of tumour vessel density in order to explore how changes in tumour vessel density correlate with response and resistance to angiogenic therapy in mRCC patients.
Here, we utilised the amplitude of nE on arterial phase CECT imaging as a surrogate marker of tumour vessel density in order to explore how changes in tumour vessel density correlate with the response and resistance to angiogenic therapy in mRCC patients.
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