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It may be a marker of underlying chronic illness and negatively impacts quality of life.
Theoretical models of Bipolar Disorder (BD) highlight that sleep disturbances may be a marker of underlying circadian dysregulation.
If she is right, facial beauty ceases to be an arbitrary characteristic and instead becomes a reliable marker of underlying desirable behaviour.
Finally, evidence increasingly points to religiosity as a mere marker of underlying physiological and genetic factors that are the true influences of health and well-being.
Halm et al. [4] explains that the degree of anemia is probably a strong, independent, prognostic factor because it is a marker of underlying comorbid illness burden and physiologic reverse.
One potential explanation is that, even in the absence of chest pain, the presence of symptoms such as dyspnoea may serve as an angina equivalent or a marker of underlying cardiac disease [47].
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The markers of underlying pathology in all these pathways can serve as markers for AD.
14 Biomarkers from the LABKA database may further be investigated as markers of underlying disease.
Infections may contribute to the aetiologic pathway and/or be markers of underlying immune modulation.
Proteinuria and hematuria may simply be markers of underlying kidney disease or other organ status [ 18, 20].
As an alternative, and possibly as an early marker of disease onset or risk, markers of underlying damage such as "hyalinosis" (amyloid) could be targeted for imaging.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com