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On the basis of these considerations, the role of TgAb measurement has evolved from a marker of thyroid autoimmunity [10, 11] to a test associated with Tg to investigate TgAb interference [12].
In the last two decades, thyroglobulin autoantibodies (TgAb) measurement has progressively switched from marker of thyroid autoimmunity to test associated with thyroglobulin (Tg) to verify the presence or absence of TgAb interference in the follow-up of patients with differentiated thyroid cancer.
Our data clearly questioned the relevance of TIMP1 as a marker of thyroid cancer.
This implies that although all ATC cell lines are dedifferentiated (absent expression of thyroid-specific genes such as Tg, TPO and NIS and positivity for onfFN), in ARO/CD133poscells a marker of thyroid organogenesis is still maintained.
The nuclear thyroid specific transcription factor TTF-1 is a homeodomain-containing protein belonging to the Nkx-2 class of homeobox genes, which is required for proper thyroid development and is used as a marker of thyroid and lung carcinoma [35].
Thus, T3RU may act as an indirect but sensitive marker of thyroid function.
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Thyroid antibodies, in particular, are frequently associated with this autoimmune disease and are predictive markers of thyroid disorders (hypothyroidism and hyperthyroidism), present in SLE with a high prevalence [22].
These promising results encouraged further research on relevant markers of thyroid tumors, taking into account more classes and subclasses of interest, as some authors have recommended [18].
We found an association between lithium exposure, as assessed by lithium concentrations in urine, and markers of thyroid function.
Recently, an effort has been made to predict the risk of thyroid cancer using the markers of thyroid function/autoimmunity [ 6– 9].
By restoring Pax8 expression, we observed the recovery of NIS expression, together with other markers of thyroid differentiation, associated to partial ability to uptake the radioiodine.
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