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In addition, there was a decrease in synaptophysin levels, a marker of synaptic viability, and changes in DNM1L levels, a protein critically involved in mitochondrial dynamics in the hippocampus of iron-treated rats13.
This possibility was examined further by measuring synaptic vesicle density in living neurons transfected with green fluorescent protein-tagged synaptobrevin 2, a marker of synaptic vesicles.
Therefore, in this study of paired plasma and CSF samples, we aimed to first characterize Ng in plasma using MS and then investigate whether plasma Ng is a marker of synaptic degeneration in AD.
To study regenerative properties of PUR, we examined the expression of neurite outgrowth protein GAP43, migrating neuroblasts marker doublecortin (DCX) and synaptophysin, a marker of synaptic plasticity, in the ischemic cortex at 14 d after stroke.
We found that spectrin immunofluorescence in the antennal lobe was reduced in the ten-a mutant compared to wild-type while N-Cadherin, a marker of synaptic neuropil, was unaffected.
Moreover, transplantation of GDAsBMP also increased levels of synaptophysin, a widely used marker of synaptic density that is decreased in Lewy body diseases like PD and that has not been addressed by other approaches.
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Medial prefrontal cortex inversely regulates toluene-induced changes in markers of synaptic plasticity of mesolimbic dopamine neurons.
Regulation of markers of synaptic function in mouse models of depression: chronic mild stress and decreased expression of VGLUT1.
Our previous studies showed that CBD is able to improve iron-induced memory deficits10 and regulate markers of synaptic viability and mitochondrial dynamics in the hippocampus of iron-overloaded rats13.
To show that the synaptic fractionation was successful, we include results with the markers of synaptic vesicles (synaptophysin) and postsynaptic densities (PSD-95).
PSD95 and synaptophysin, markers of synaptic density (30, 31), were unaffected by UE2316 (Table 2).
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