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Future studies investigating the use of combined automatically generated smartphone data (and other biological and clinical measures) as a marker of risk, a marker of diagnosis, a marker of state, a marker of stage, a marker of treatment response and a marker of prognosis (McIntyre et al. 2014; Davis et al. 2015) would be groundbreaking.
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There were 41 tumor/germline reported markers of stage; 27 (65.9%) were excluded.
In addition, SOREMPs may be detected early in the disease and so are not specific markers of stage 2 HAT.
However, several findings suggest that NLR was an independent prognostic marker regardless of stage.
In addition to identifying markers of staging and severity, this model reveals that OP participates in the repair of aspiration-induced injury.
Gene expression analyses indicate that HGF coating enhanced osteoblast differentiation as demonstrated by increased runx2 (a transcription factor important for osteoblast lineage and differentiation), alkaline phosphatase (marker of mid stage differentiation) and osteocalcin (marker of late stage differentiation) mRNA levels.
Further supporting these findings, we found that PD-1low T cells, especially PD-1lowCD8+ subset, constitutively expressed high level of 2B4, a marker of late stage exhaustion, and lacked expression of OX40, a co-stimulatory molecule.
We also found 134 significant proteins in the specific network marker of early stage bladder cancer and 32 significant proteins in the specific network marker of late stage bladder cancer.
Previous studies have demonstrated the utility of pSer129 α-syn measurement as a marker of disease stage [ 43, 44] and shown that the level is generally higher in DLB and PDD than in PDND [ 45].
Alkaline phosphatase (ALP) is a typical marker of early stage osteoblastic differentiation (Owen et al. 1990).
In 3xTg-AD mice, tau pathology becomes apparent between 12 to 15 months of age and staining with PHF1 antibody, a marker of late stage of tau pathology, is evident at 18 months of age [36].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com