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These results lend support to the hypothesis that impaired semantic fluency may be an early trait marker of schizophrenia that is potentially related to a failure of lateralisation of language.
Pattern classification of functional MRI measurements of language processing is a potential diagnostic marker of schizophrenia.
Reduction of the amplitude of the P300 component of the event-related potential (ERP) is the most replicable biological marker of schizophrenia [ 3].
This study is in line with the assumption that the reduced N1/P2 amplitudes might represent primarily a trait marker of schizophrenia.
Taken as a whole, the data from this study strongly argue against Oct-6 being a marker of schizophrenia or any other psychiatric condition.
In the recent meta-analysis by Miller et al. [ 4], IL-6 was found to serve as a state marker of schizophrenia, which is increased in first-episode psychosis and acutely relapsed patients, and prone to normalize with antipsychotic treatment.
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Significantly, the increase in the right IPL signal was found to correlate positively with the severity of first-rank symptoms, and thus could be considered a "state-marker" of schizophrenia, whereas temporal and medial parieto-frontal differences appear to be "trait-markers" of the disease.
In this study we screened PBL of 13 drug-naive/drug-free schizophrenic patients to identify additional markers of schizophrenia.
Disturbances in sensory gating are thought to be endophenotypic markers of schizophrenia (Braff, 1993; Bredgaard and Glenthoj, 2000).
Previous studies demonstrated that the deficits in facial emotion recognition of the first degree relatives might be potential markers of schizophrenia [ 14].
Both traits are important phenotypes for genetic studies and potential early clinical markers of schizophrenia-spectrum disorders.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com