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Knowledge of the normal range of optic nerve sheath diameter in a healthy population is essential to interpret this measurement as a marker of raised intracranial pressure in clinical practice.
Low HDL cholesterol might merely be a long-term marker of raised TG and remnant cholesterol.
Papilledema, however, is not a sensitive marker of raised ICP and can take several days to develop [ 10].
Where E/e' was inconclusive (8 to 15), increased left atrial area (> 20 cm) was used as a marker of raised LV filling pressure (pseudonormal pattern).
Based on these results and when brain MRI is indicated in situations at risk for increased ICP, the optic CSF thickness measurement could be systematically performed and used as a surrogate marker of raised ICP.
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Forty-seven scans were for the assessment of residual masses (18 had raised markers) and 23 scans were for the investigation of raised markers in the presence of normal CT scans.
As a result of this it was suggested that in the presence of raised marker levels and negative imaging (including negative PET), the most appropriate follow-up imaging may be repeat PET.
Patients with testicular cancer can also present with recurrence suspected on the basis of raised markers.
For the assessment of residual masses and finding disease in the presence of raised markers, it has been found to be very valuable.
The attenuation of associations of TNFα with outcome confirms findings in a recurrent stroke study, that a profile of raised inflammatory markers (rather than any specific independent inflammatory marker) is associated with vascular risk [16].
Our data, demonstrating an association of C-peptide levels with markers of endothelial activation such as ICAM-1, VCAM-1, and E-selectin, as well as a highly significant association with levels of LpPLA2, a novel marker of arteriosclerosis, raise the question if C-peptide could potentially also directly influence atherogenesis in humans, but our data cannot prove a causal relationship.
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