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Treatment with biAP significantly attenuated the increase in median plasma creatinine levels and the urinary excretion of a marker of proximal tubule injury, glutathione-S-transferase A1.
Impairment of B2MG tubular uptake results in a raised urinary excretion, so B2MG level in urine has been taken as marker of proximal tubular dysfunctions [23].
The present investigation was designed to determine (1) if these atrial peptides enhance protein excretion and (2) if their effects involve the proximal tubules of healthy humans by examining the excretion rate of β2-microglobulin, a marker of proximal tubule function.
Therefore, the presence of AMBP in urine is indicative of reduced resorptive capacity of the proximal tubule [35]; consequently, the urinary concentration of AMBP, which is stable at low pH, designate this protein as a useful marker of proximal tubular abnormalities and chronic asymptomatic renal tubular dysfunction [36].
A deficiency in nephrogenic structures in Ptc1−/−UB kidneys was confirmed by examining the expression of PAX2, a marker of condensing mesenchyme and early nephrogenic structures (Figure 2G,K) and LTL, a marker of proximal tubules (Figure 2 H,L).
β2m is a low molecular weight protein and an established marker of proximal tubular function.
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Alpha-1 microglobulin (AMBP; AMBP) and retinol binding protein (RBP) are low molecular weight markers of proximal tubular dysfunction [ 11– 13].
Kidney function and the markers of proximal tubular injury should be carefully monitored in patients receiving rifampin.
Renal function was also estimated by measurements of (i) GFR, (ii) the fractional excretions of sodium and glucose (markers of proximal tubular dysfunction) and (iii) urine osmolality.
Induction of inducible nitric oxide synthase and renal nitric oxide metabolite production was reduced, as was the excretion of markers of proximal tubule damage.
Urine volume was measured, and creatinine, glutathione S-transferase (GST) alpha (A1-1) and pi (P1-1), as markers of proximal and distal tubule injury, respectively, were measured [ 21].
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