Using antibodies against the marker of proliferation PCNA (proliferating cell nuclear antigen), we showed that treatment with LPC causing demyelination provoked a proliferative response, which subsided with remyelination.
Ki-67 is a commonly used marker of proliferation in tumors and is universally expressed among proliferating cells and absent in quiescent cells.
This theoretically makes MCM2 a much more sensitive marker of proliferation, since it detects cells that are "licensed to proliferate" and capable of initiating DNA replication [ 18].
In contrast, Geminin is a more specific marker of proliferation, as it only detects cells that are "committed to proliferate" [ 38].
Ki-67 is a well-known histological marker of proliferation used as an index of biological aggressiveness in various solid tumors.
Several small studies have shown a correlation between the uptake of FLT and the histopathological marker of proliferation Ki-67 [5].
FLT is used as a marker of proliferation, and retention of FLT is believed to be related to the phosphorylation of the radiotracer by TK1.
As [18F]FLT is a biomarker of cellular proliferation, we investigated the relationship between Ki-67, a histologic marker of proliferation with the PET variables SUVmean and SUVmax.
In a reaction mediated by TK-1, [18F]FLT is phosphorylated to [18F]FLT-monophosphate which is not incorporated into the DNA but remains trapped within the cytosol where it accumulates, thereby acting as a marker of proliferation [22].
CD105 has been described as a marker of proliferation and adhesion [22].
No differences in Ki67, a marker of proliferation, were seen (data not shown).
