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ICA is thought not to change after the onset of age-related neuronal loss, particularly in men, therefore can be used as a marker of peak brain size, thus allowing the outcome variable to be more reflective of brain atrophy [ 48].
These findings were corroborated in patients (n=123) with SCD, in whom plasma PlGF levels were associated with anaemia, an increase in ET-1 levels and increased tricuspid regurgitant velocity (TRV); the latter a marker of peak pulmonary artery pressure [ 6].
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b Nearest marker to peak of the detected QTL and its map position (in Kosambi cM).
In the case of traits like drought tolerance, where gene-linked markers are not available, the identification of peak markers and flanking markers in the recipient background within the QTL region is necessary at the initiation of a MAB program.
In contrast, concentrations of BC, a marker of diesel exhaust, peak near 0600 hours.
In addition, a marker of young cartilage, peak 2414.9 identified as collectin-43, was demonstrated.
Shown are the peak position of QTL A and QTL B; flanking markers of both peaks; F-value and significant threshold (*chromosome-wide P < 0.05) reached under 2 vs 0 QTL (F-statistic for testing two QTL vs no QTL on chromosome), or 2 vs 1 QTL (F-statistic for testing two QTL vs one QTL on chromosome); standardised QTL effect (SD) and standard error (SE).
fCross-validated proportion of explained genotypic variance of peak marker.
Kruskal Wallis ranking test was used to confirm the influence of peak markers defined in the linkage analysis on phenotypes, and p values ≤ 0.05 after Bonferroni correction [85] were considered significant.
Hierarchical cluster analysis of various clinical and transcriptomic markers using time index of peak measurements (time after injury to reach maximum values; Fig. 6) was applied in order to identify and illustrate common expression patterns and their temporal relationships in patients with a similar clinical course and outcome with respect to nosocomial infections and sepsis.
Seven of the BINs containing the peak marker of a resistance QTL also contain a Prx Profiling marker confirmed to be homologous to a known Prx (viz. 1H_12.2, 2H_4.2, 2H_15.1, 3H_5.2, 5H_12.1, 6H_8.1, 7H_7.2) (Table S2).
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