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The increased levels of FKBP12 in neurons situated in areas of degeneration suggest that it may become a novel marker of pathology.
Although KRT16 and K6A and K6B are defined as "epidermal" genes [ 52], their expression in epidermal keratinocytes is a marker of pathology.
These results suggest that this task is sensitive to mild hippocampal atrophy and thus might be a sensitive cognitive marker of pathology associated with preclinical AD.
This is in particular of interest as perfusion may precede actual changes in structure or even function and could thus potentially be a very early marker of pathology.
Concentrations of cell-specific MV in blood have the potential to be a diagnostic/prognostic marker of pathology, but ranges of MV must first be established in healthy individuals.
Astrocytes, however, may also normally undergo hypertrophy in the late fetal and perinatal white matter as an obligatory developmental change, potentially due to the "physiological oxidative stress" of active myelin sheath synthesis, and thus may not be a marker of pathology at all [ 15].
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The data are in alignment data reported in other studies in these animal models, demonstrating that the presence of neoepitopes is a good biochemical marker of pathologies involving excessive ECM remodeling [ 21- 27].
The apparent mismatch between molecular and cellular markers of pathology merits further consideration.
It will also be of great interest to perform multimodal in vivo studies combining MRI measures of cortical thickness with imaging markers of pathology (Buckner et al. 2005).
Compared to measurement of the intact/whole protein, the measurement of such modified 'fingerprint' peptides are likely to be more sensitive markers of pathology.
The structure of snoRNAs, their expression pattern, and localization within cells have regulatory significance and are considered diagnostic markers of pathology.
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