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But down deep, I nurtured an almost electric thrill at meeting this marker of "objective" teaching success.
These studies indicate that induction of manageable autoimmunity in patients with metastatic melanoma treated with ipilimumab could be a surrogate marker of objective and durable clinical response.
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Some of this inconsistency may be due to the use of self-reported markers of asthma which are potentially biased, but use of objective markers such as bronchial hyperresponsiveness (BHR) is rare.
This lack of objective marker has hampered FM recognition and research.
As it is now widely accepted that US is more accurate than standard clinical examination at detecting synovitis [ 25], and PD technologies further improve the capability of identifying actively inflamed joints [ 31], the association with PD scores found here makes CXCL13 a valuable surrogate marker for quantitative assessment of objective and pathologically relevant disease processes in RA.
The addition of objective markers of SHSe may help to clarify the role of SHSe on dental caries.
Collection of objective markers of lung function and measures of allergic disease in siblings discordant for CS would also provide important data, as would information on maternal choice of delivery.
Advantages of this study include the prospective randomised design, the blinding of all patients and evaluators, and the complementary use of objective markers of infections that is, bacterial cultures and blood chemistry.
This lead to investigations of objective markers, to be set as surrogate goals for therapy thereby increasing the probability of long-term favourable outcome.
The findings reported here and the lack of agreement among myriad studies highlight the limitations associated with subjective measures and encourage the use of objective markers.
In the absence of objective markers, most published trials define a moderate-severe exacerbation as one requiring admission to hospital or intravenous antibiotics.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com