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The aim of our research was an evaluation of possibility to use PRAME gene expression as a marker of minimal residual disease (MRD) in multiple myeloma (MM) patients.
These cells are therefore assumed to be a surrogate marker of minimal residual disease and precursors of distant metastasis.
Based on the pooled analysis of the bone marrow (BM) micrometastasis group, disseminated tumour cells (DTC) are a surrogate marker of minimal residual disease.
To assess the potential effect of vaccination on leukaemia, WT1 mRNA expression was used as a surrogate marker of minimal residual disease.
Our results also demonstrate that capillary blood ammonia is not an accurate biological marker of minimal HE in patients with cirrhosis, nor a reliable predictor of future episodes of overt HE during follow-up.
The reappearance of the JAK2 gene mutation after transplant was associated with the presence of mixed chimerism and relapse; thus, JAK2 mutation serves as a marker of minimal residual disease.
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Chromosomal alterations in leukemia have been shown to have prognostic and predictive value, and are also important markers of minimal residual disease in the follow-up of leukemia patients [2].
In that way, sampling of laboratory markers are of minimal burden for the patient.
The clustered BES markers, while of minimal utility in fine ordering of physical map contigs for QTL analysis within these regions or assisting in whole-genome assembly, do provide gross assignment of physical map contigs to linkage group regions.
Besides being pathogenic, aquaporin 4 Abs are used as a marker of 'minimal residual afterfter SCT.
This experiment demonstrates that donor templates can be designed for the incorporation of discontinuous exogenous DNA sequences an approach that enables careful placement of the visible marker for minimal disruption.
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