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In particular, it is not known if these masses may increase in size and, above all, whether this is a marker of malignant transformation or whether malignancy may also occur without size variation.
The presence of a long-lasting fluoroscopically visible marker of malignant lymph nodes would facilitate subsequent radiation and surgical therapy.
Immunohistochemically, these epithelioid tumor cells were positive for epithelial membrane antigen (EMA), a marker of malignant mesothelioma, with more than 50% positive for p53.
Degree of dysplasia, not the amount of resected pancreas, was associated with increased risk of DM, suggesting that the presence or development of DM may be a marker of malignant progression.
Moreover, IGFBP-2 is a highly sensitive marker of malignant progression in different tumors and potentially involved in anti-apoptosis, angiogenesis, and metastasis during cancer progression [27].
In addition, gp240 is recognized as a marker for multipotent early oligodendrocyte progenitors in normal CNS [15], [16] and its increased co-expression with CD44 has been proposed as progressive marker of malignant gliomas [17].
Similar(34)
Alterations in specific oncogenes and tumor suppressor genes that serve as surrogate markers of malignant transformation have been identified in ovarian cancers.
Global changes in histone H4 modifications seem to be universal markers of malignant transformation [ 4], while other histone marks predict the prognosis of prostate cancer [ 5].
Thus N-cadherin expression correlates with the expression pattern of immunohistochemical markers of malignant germ cell tumours such as CD117, PLAP and AFP.
In particular, MMP-2 and MMP-9 (also known as gelatinase-A and gelatinase-B) are most linked to the malignant phenotype of tumor cells and are commonly used as markers of malignant cancer.
Expression of miR-21 and miR-155 in the entire group of pathologically borderline melanocytic lesions was evaluated in the context of two markers of malignant potential, mitotic activity and depth of invasion.
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