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At present, a molecular marker of malignancy would be of great interest to distinguish benign from malignant melanocytic tumors.
CXCL12 is present in ovarian epithelial cells before they become malignant and is therefore not useful as a marker of malignancy in EOC.
We aimed to determine if MCM proteins are dysregulated in malignant pancreaticobiliary disease and if levels in bile are a sensitive marker of malignancy.
Among Dr. Croce's peers, there was skepticism of Dr. Croce's broad claims for the FHIT gene, and today some scientists say it seems more a marker of malignancy than the "Rosetta Stone" of cancer research, as some news reports called it at the time.
Thus it is abundantly clear that native NIS expression in breast cancer cannot serve as a useful marker of malignancy.
Although NIS expression is significantly higher in malignant compared to normal breast tissue, the highest level was detected in fibroadenoma, indicating that NIS expression in breast cancer cannot serve as a useful marker of malignancy.
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Ki-67 expression by proliferating tumor cells is a well established prognostic marker of malignancies including ML [ 26, 27].
In this stage only benign lesions were selected in order to avoid associations caused entirely by the fact that features considered as markers of malignancy frequently coexist in malignant lesions.
These studies have either searched for specific markers by comparing a particular class of thyroid tumor to the corresponding normal tissue, or looked for markers of malignancy by examining the most frequent benign and malignant classes of thyroid tumor (usually the FTA and PTC classes).
There were numerous studies on the topic of US markers of malignancy and panels of combined markers in the differentiation between benign and malignant thyroid lesions [ 8].
These tools permit the easy selection of genes that are preferentially expressed in cancer tissues and therefore have the potential to serve as molecular markers of malignancy.
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