SOMETIMES small elections are markers of major political change.
Thus, hub genes can help identify new biomarkers of tumor progression, metastasis and other markers of major phenotypic changes.
These correlations are so relevant that these comorbidities have been proposed as markers of major severity, rather than just associated conditions [ 19].
For the first time, we determined the relationship between telomere length and tumour progression and location, as well as its relationship to MSI and p53 mutation status, two markers of major pathways of genetic instability in CRCs.
Mammaglobin (MAM) and maspin are markers of major interest because some evidence indicates that they have a stronger relationship with breast tissue than several other epithelial markers such as cytokeratins, CEA and MUC-1 (Luppi et al, 1996; Zach et al, 1999; Grünewald et al, 2000; Ballestrero et al, 2001; Corradini et al, 2001; Silva et al, 2002; Zehentner and Carter, 2004).
Thus, telomere attrition can serve as a marker of these major carcinogenic pathways.
Thus, the search for new markers is of major interest for early detection of CRC and identification of new potential therapeutic targets.
Limiting the amount of crosstalk in prospective markers is of major importance, because it will allow the imaging of dense samples without prior bleaching.
We found that XIST and KDM5C gene expression may be used as a biological marker for diagnosis of major affective disorders in a significantly large subset of female patients from the general population.
Lung cryosections were fixed with acetone, blocked with 10% normal mouse serum and stained with peroxidase-conjugated mAbs (all from BD-PharMingen, San Diego, CA) against the surface markers of the major lymphocyte populations, CD4+ T cells, CD8+ T cells, CD19+ B cells, and Ly-6G+ neutrophils, to assess the architecture and cellular content of inflammatory foci in the lungs.
