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Membrane RAGE is highly expressed on epithelial type I cells in the lung and consequently has been suggested to be a marker of loss of epithelial type I cells [30].
Upregulation of 5T4 expression is a marker of loss of pluripotency in the early differentiation of embryonic stem (ES) cells and forms an integrated component of an epithelial-mesenchymal transition, a process important during embryonic development and metastatic spread of epithelial tumors.
We have recently shown that upregulation of 5T4 expression is a marker of loss of pluripotency in the early differentiation of human and murine embryonic stem cells [13], [14] and forms an integrated component of an epithelial-mesenchymal transition (EMT) [15], [16].
Considering alternative explanations, it is also possible that loss of language lateralization is an epiphenomenon of psychosis: in this case language represents a good marker of loss of integration among a number of more basic processes and areas in schizophrenics' brain.
Microerosions without loss of barrier function were uncommon so the presence of microerosions is likely to be a marker of loss of barrier function.
Thus, simplistically, absence of PR expression may simply be a marker of loss of normal ER pathway function that would account for the relative unresponsiveness to endocrine therapy that we have demonstrated in this study.
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These were all signs of necessary growth, but also markers of loss as relationships shifted.
Figure 3 illustrates the possible advantages of markers of structural changes over markers of loss of kidney function.
The only markers currently accepted and used in clinical practice for the diagnosis and prognosis of CKD are markers of loss of kidney function.
Second, blood transfusion is a surrogate marker of blood loss, and therefore changes in blood losses should have reflected better the efficacy of FBNc.
The task might then provide a potential marker for loss of control of drug seeking in addicted patients.
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