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It added: "Earlier alcohol use is associated with early onset of sexual activity and is a marker of later sexual risk-taking, including lack of condom use, multiple sexual partners, sexually-transmitted infection and teenage pregnancy".
Even though we could not detect any major modifications in myelin structure in Ins2Akita/+ PNS (Fig. 3A C), subtle molecular alteration in myelin gene expression could provide an early marker of later stage irreversible pathological changes.
In contrast, we hypothesized that since IL-6 is typically a marker of later inflammation, and indeed may be a hallmark of the positive feedback cycle of inflammation→tissue damage/dysfunction→inflammation, then elevations in this cytokine are indicative of a harmful, self-sustaining inflammatory response.
In our series, leptin rather than insulin acts as a marker of later adiposity.
At present, there is not an extensive literature examining cord leptin as a marker of later obesity.
Here, we determine whether viral load in cervical smears is a risk marker of later developing invasive cervical cancer.
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In general, markers of later stages of differentiation such as involucrin and filaggrin were not decreased.
This suggests that some features of JA may be early markers of later psychopathology.
We show that cells present in 8- and 16-cell embryos variably express a number of markers of later lineages, as was also seen in a previous study (Guo et al., 2010).
However we are now in a position to use shorter-term intermediate outcome markers of later disease risk to monitor and promote a healthy start to life programmes such as those in pre-conception care.
We also know that, for ASD in particular, while differentiation of siblings who experience later problems within the first year of life is difficult, there is a constellation of phenotypes that emerge after 12 months that may be key markers of later difficulties.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com