Six metabolites emerged as markers of key differences between the two groups: uric acid, L-histidine, hypoxanthine, glutamic acid, L-tryptophan, and ADP.
These eicosanoids are therefore markers of key processes in the pathophysiology of endotoxaemic shock.
Other assays have utilized specific markers of key events in the process of apoptosis or necrotic cell death.
Several methods of identifying cell death in the kidney are based on specific markers of key biochemical events in the process of necrosis/oncosis or apoptosis, for reviews see [ 2, 3, 7].
These findings reveal important transcriptionally regulated markers of key biological processes, including genes involved in inflammatory responses, immune defense, cell activation, homeostatic processes, and regulation of cell proliferation and apoptosis.
Therefore, in addition to validating individual predicted direct miRNA-122 target gene expression to assess functional efficiency of miRNA-122 inhibition in trout, we focused on analyzing the expression of non-target markers of key hepatic metabolic pathways to elucidate the underlying (indirect) molecular mechanisms for the observed metabolic consequences in vivo.
Our approach has been to use functional markers of key molecular pathways of tamoxifen resistance to seek to identify a panel that can select patients who may either derive sufficient benefit from treatment with tamoxifen alone, or for whom withdrawal of adjuvant therapy, which is moderately toxic, may pose minimal risk.
The identification of informative markers of key events can be greatly enhanced by the use of whole genome techniques such as gene expression assessments [using microarrays or preferably mRNA counting techniques such as SAGE or ultra-high throughput sequencing (Mardis, 2008)], or proteomic assessment [using mass spectrometry based techniques (Latterich et al., 2008)].
These results suggest that CCR7 is a marker of a key subset of Treg that may protect against BOS.
Eight functional markers of three key carotenoid genes PSY1[ 12], lcyE[ 33] and crtRB1[ 34], (previously developed using different association panels of diverse temperate, sub-tropical and/or tropical yellow maize inbred lines), were considered for validation in this study.
