High-fat and/or high-sugar feeding studies examining the liver transcriptome have reported that inflammatory and lipid metabolism markers increase while oxidative stress defense markers decrease following 4 20 weeks of high fat diet feeding [ 5– 8].
We found that 12/15LO deficiency protected mice from exhibiting elevated inflammatory markers in adipose tissue and, remarkably, prevented whole-body insulin resistance induced by 2 4 weeks of high fat feeding.
Increased expression of hepatic inflammatory markers and suppression of the anti-inflammatory marker suggested that high fat diet favoured an increased inflammatory response, in keeping with earlier findings [ 13].
Thus, the present study aimed to investigate the causal effect of high-fat diet upon vascular inflammatory markers and its relationship to aortic stiffness.
In animal models, 12 weeks of high-fat feeding increased NADPH oxidase, an important marker in the generation of oxidative stress, and accelerated the pathogenesis of endothelial dysfunction [86].
114 Treatment of high-fat-fed animals with resveratrol causes improvements in insulin sensitivity and decreases markers associated with aging.
Which Kinds of Foods Make Us Fat? Beware of high-fat diets.
