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The body weight, though subject to difficulties and possible errors in measurement is an indirect marker of fluid overload.
In our patients, mean ΔSVC, which has previously been validated as a marker of fluid responsiveness [31], was similar in survivors and in non-survivors.
Besides routine ICU measurements, including risk factors for developing AKI, three study measurements were performed at inclusion: RRI, sublingual sidestream dark field imaging (SDF) to visualise microcirculation, and Bioelectrical Impedance Analysis (BIA) as a marker of fluid status.
This emphasises the value of central venous pressure (Fig. 2), which should not be used to decide to give fluid, since it is not a reliable marker of fluid responsiveness, but which is a reliable marker of the right heart function.
To determine whether extracellular rPrP cell surface binding can similarly induce macropinocytosis, we co-incubated N2a cells with a fluorescent marker of fluid phase macropinocytosis, 70-kDa dextran-FITC [44], and increasing concentrations of rPrP (Figure 3B).
Previous studies have shown that CVP is a poor marker of fluid responsiveness in critically ill patients [ 11].
Similar(41)
Similarly, only monocytes internalized large amounts of dextran (Fig 1E), a marker of fluid-phase endocytosis, and confocal microscopy demonstrated intracellular co-localization of fluorescently labelled N-BP with dextran (Fig 1F).
Previous studies have demonstrated that traditional markers of fluid balance correlate poorly with acid base status and respiratory function.
Many studies have focused on the prediction of fluid responsiveness, and many different dynamic markers of fluid responsiveness have been studied in recent years [ 1, 5– 7].
Markers of fluid responsiveness were compared between responders (CI ≥15%) and nonresponders to a colloid fluid challenge (5 ml/kg IBW).
These dynamic markers of fluid responsiveness are more reliable than traditional techniques [ 72] and more practical to use than fluid challenges guided by stroke volume change.
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