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The prognostic value of KLK15 is similar to that of hK3 (PSA) which is also an independent marker of favourable prognosis in breast cancer (Yu et al, 1995).
Thus the presence of COX-2 expression in these tumours appears to be a marker of favourable prognosis closely linked to the degree of tumour differentiation.
Daily CRP measurement is useful in monitoring the clinical course of severe CAP and is a good early marker of favourable outcome.
In a more recent study, Oduwole et al suggest that low expression of 17HSD type 2 in colon cancer is an independent marker of favourable prognosis in females.
This model is harmonious with the identification of Wnt5a expression as a marker of favourable outcome in early CRC (Dejmek et al, 2005).
In conclusion, we herein highlight for the first time the importance of Sox11 tissue expression as an independent marker of favourable significance, strengthening its tumour suppressor function in astroglial tumours.
Similar(51)
Importantly, genetic defects have therapeutic relevance; markers of favourable (WNT activation) and poor (MYC/MYCN amplification) prognosis have been identified and validated in clinical trials cohorts [6], [9], [10], and small molecule inhibitors of the SHH pathway are under pre-clinical development [11].
Two kallikreins, KLK9 (Yousef et al, 2001) and KLK14 (Yousef et al, 2003a), are markers of favourable prognosis.
Wnt5a is ubiquitously expressed in normal tissues (Ying et al, 2008), but is often dysregulated in tumours (Wang et al, 2007, 2010) and has been controversially implicated in both tumour suppression and oncogenesis in addition to being recognised asa marker of both favourable and poor outcome in primary cancer.
Gruvberger-Saal et al [ 38] reported that the expression of ERβ is an independent marker for favourable prognosis after adjuvant tamoxifen treatment in ERα negative breast cancer patients.
PR and ER are markers of a favourable prognosis in breast cancer and characterize specific subtypes of the disease.
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