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Serum γ-glutamyltranspeptidase (GGT), a marker of fatty liver disease (FLD), predicts mortality in young adults.
As a marker of fatty acid oxidation, we measured the appearance of 3-OHB in the medium.
Some studies suggest that bilirubin, which is inversely related to insulin resistance and oxidative stress, 42 may be another interesting marker of fatty liver.
As a marker of fatty acid oxidation, we measured the appearance of H2O using a Finnigan GasBench-II (ThermoFisher Scientific, UK) in the medium that would have been derived from the [D31]palmitate added to the culture medium (29, 51).
γ-GTP is a marker of fatty liver disease and γ-GTP levels have been found to be associated with the prevalence of MetS in previous East Asian studies [ 20- 22].
Significant reductions in levels of alanine aminotransferase, a marker of fatty liver disease, and increased adiponectin levels observed in SERENADE suggested a potentially beneficial effect of rimonabant on insulin resistance.
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Nonetheless, additional controlling for hepatic enzymes - markers of fatty liver, did not substantially change the results (data not shown).
Our results are in agreement with the latter study as we observed that, six months after LAGB intervention, MHO individuals had a significant improvement in cardio-metabolic risk factors including an increase of insulin sensitivity, β-cell function, and HDL cholesterol, and a reductions of fasting glucose and insulin levels, triglycerides, and liver enzymes (surrogate markers of fatty liver).
In our diabetic hearts, we found markers of fatty acid oxidation, such as UCP3, were upregulated.
These genes are potential markers of fatty acid uptake, binding, storage and oxidation.
Our results indicate that activation of the HSR by MES + HS improved surrogate markers of fatty liver.
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