Bone disease is the most characteristic marker of end-organ or tissue damage in MM.
Still, we cannot entirely rule out the possibility that anemia was a marker of end-stage COPD, and therefore associated with increased mortality.
We also performed a sensitivity analysis to rule out that 25(OH D is a marker of end-stage disease in this population by excluding subjects who died within 2 years of follow-up, leaving 1,561 subjects.
It is plausible, therefore, that the delirium experienced among our patients is not only a marker of end-organ damage, but also acts directly as a promoter of other organ system dysfunction.
Respondents were not confident in identifying features of severe sepsis and with the exception of hypotension despite fluids, other markers of end organ dysfunction were underreported.
A compendium of techniques that can be used to quantify these two markers of end-stage cell death in vitro and in vivo goes beyond the scope of this review and can be found in several recent articles.
Rosiglitazone reduced renal injury [ 147] and improved other markers of end-organ damage [ 148] in murine sepsis models, while ciglitazone reduced bacterial burdens and local inflammation in a murine model of pneumococcal pneumonia [ 149], suggesting that thiazolidinediones may find use as an adjunctive treatment for sepsis [ 150].
For others, it's a morality tale about class, or a foreshadowing of the First World War — the marker of the end of a more innocent era.
With the marker of the end of the year and the start of the new one, with the eternal wheel rolling ahead yet returning to the same point, it's worthwhile to join Lubitsch in taking the long view of our earthly strivings — and remembering to canonize, as he does, their fleeting joys for all time.
