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The original trial elected to use blood transfusion as a surrogate marker of bleeding, a widely accepted but still imperfect marker.
Regarding the issue of BNP alteration in trauma patients, Kia and colleagues [ 15] reported BNP levels below normal as an indicator for intravascular volume loss and therefore as an initial marker of bleeding.
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In this group, treatment with rFVIIa significantly reduced the need for all blood products, surrogate markers of bleeding, as well as potential donor exposure as compared with placebo during standard-of-care management of hemorrhage (Table 4).
Using blood transfusions as a surrogate marker for bleeding can be seen as relevant because of the unreliability of visual estimation of blood loss.
We do not recommend the use of single Hct measurements as an isolated laboratory marker for bleeding (Grade 1B).
We do not recommend the use of single Hct measurements as an isolated laboratory marker for bleeding.
Nonetheless, after elimination of other possible causes of bleeding, we found a correlation between our commonly used markers of fibrinolysis and specific genotypes.
"Not in a month of bleeding Sundays.
Use of POP can cause a variety of bleeding patterns including amenorrhoea, infrequent bleeding, frequent bleeding and prolonged bleeding episodes.
anticoagulation stop in case of bleeding 5.
Grading of bleeding according to the World Health Organisation.
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